H Bhl
DRP595 175 I. G. Farben 1931 . DRP590 175 I. G. Farben 1932 . Formulation s amp. 0.5g 5 g 10 as sodium salt D Dormopan Bayropharm -comb. wfm Evipan Bayer wfm Stodinox Lorenz -comb. wfm F Dormopan Bayer-Pharma -comb. wfm Noctivane Vaillant-Defresne wfm GB Evidorm Winthrop wfm J Cyclopan Teikoku Kagaku-Nagase Oltopan Dainippon Ouropan Soda Shionogi USA Sombulex Riker wfm rn 54-03-5 MF C H NAo MW 592.69 einecs 200-189-1 LD,0 34 mg kg r, i.v. cn 3,4,5-trimethoxybenzoic acid ester rn 50-62-4 MF CjoH...
Ixgxh
methyl 3ap7a-diacetoxy-12ot-hydroxycholanate I methyl 3a,7a-diocetoxy-12-oxocholanote II 1. H2N-NH2 .H2O. HO- OH - 200 C methyl 3a,7a-diocetoxy-12-oxocholanote II Fieser, L.F. Rajagopalan, S. J. Am. Chem. Soc. JACSAT 72, 5530 1950 . Hauser, E. et al. Helv. Chim. Acta HCACAV 43, 1595 1960 . Hofmann, A.F. Acta Chem. Scand. ACHSE7 17, 173 1963 . Sato, Y. Ikekawa, N. J. Org. Chem. JOCEAH 24, 1367 1959 . DOS 2 302 744 Union International appl. 20.1.1973 GB-prior. 20.1.1972 . DE 2 404 102 Schering AG...
Info Scc
ethyl 5-ethoxy-4-methyl-axazale-2-carboxylate VIC K nig, H. Boll, W. Chem.-Ztg. CMKZAT 100, 105 1976 . a Harris, E.E. et al. J. Org. Chem. JOCEAH 27, 2705 1962 . DAS 1 470 022 Merck amp Co. appl. 10.5.1962 USA-prior. 15.5.1961, 16.1.1962 . US 3 227 721 Merck amp Co. 4.1.1966 prior. 15.5.1961, 16.1.1962, 24.5.1965 . US 3 227 724 Merck amp Co. 4.1.1966 prior. 15.5.1961, 16.1.1962, 16.6.1964 . b US 3 222 374 Roche 7.12.1965 prior. 22.5.1963, 20.11.1964 . US 3 250 778 Roche 10.5.1966 appl....
Info Kan
by fermentation 0 from Soccharomyces genus b from ornithine c from Arthrobacter 1 Fox, S.W. J. Biol. Chem. JBCHA3 123, 687 1938 . 2a JP52 143 288 Kyowa appl. 20.5.1976 . 2b JP 50 148 588 Miura appl. 23.5.1974 . 2c JP 53 075 387 Kyowa appl. 13.12.1976 . JP 12248 67 Ajinomoto appl. 11.9.1965 . JP 117 58 68 Kyowa appl. 15.11.1965 . Fox, S.W. et al. J. Org. Chem. JOCEAH 6, 410 1941 . JP7 100 174 Ajinomoto appl. 20.11.1968 . isolation from Citrullus vulgaris Schrad. Wada, M. Biochem. Z. BIZEA2 224,...
Info Mmj
US 1 526 627 Bayer 1925 prior. 1924 . Formulation s amp. 400 mg 2 ml drg. 25 mg, 50 mg, 100 mg drops 20 mg ml susp. 50 mg 5 ml vial 50 mg ml D Endojodin Bayer wfm I Endojodo Cozzolino wfm Jodopropano Trijodina Lafare wfm Farmochimica Ital. wfm USA Entodon Winthrop wfm Neoiodorsolo os Baldacci -comb. wfm Use neuroleptic, anti-emetic, antipsychotic RN 58-40-2 MF C17H20N2S MW 284.43 E1NECS 200-382-0 LDJ0 45 mg kg M, i.v. 401 mg kg M, p.o. 14.5 mg kg R, i.v. 350 mg kg R, p.o. CN RN 53-60-1 MF...
Info Rok
US 2 738 301 Merck amp Co. 1956 appl. 1950 . US 2 738 302 Merck amp Co. 1956 appl. 1950 . FR 1 336 671 Merck amp Co. appl. 28.2.1962 USA-prior. 13.3.1961 . Formulation s amp. 0.5 mg 1 ml cps. 460 mg vial 5 mg, 10 mg as hydrochloride Trade Name s FR 1 336 671 Merck amp Co. appl. 28.2.1962 USA-prior. 13.3.1961 . Formulation s amp. 0.5 mg 1 ml cps. 460 mg vial 5 mg, 10 mg as hydrochloride Trade Name s
Eflornithineatc PCX
DFMO RMI-71782 antineoplastic, antiprotozoal, inhibitor of ornithine decarboxylase, anti Pneumocystis RN 67037-37-0 MF QH12F2N202 MW 182.17 LD50 gt 3000 mg kg M, i.p. gt 5000 mg kg M, p.o. 1364 fig kg R, intracerebral CN 2- difluoromethyl -DL-ornithine RN 68278-23-9 MF C6H12F2N202 - HCl MW 218.63 EINECS 269-532-0 monohydrochloride monohydrate RN 96020-91-6 MF C6Hl2F2N202 HCl H20 MW 236.65 N2,N5-dibenzylidene-ornithine methyl ester
Info Png
2. HjC S CI , N C2H5 j, CH2CI2 EP 387 077 Wisconsin Alumni Res. Found. 12.9.1990 appl. 9.3.1990 USA-prior. 16.2.1990 . W0 9 729 740 Wisconsin Alumni Res. Found. appl. 5.9.1996 USA-prior. 13.2.1996 . Paaren, H.E. et al. J. Org. Chem. JOCEAH 45, 3253-3258 1980 . Paaren, H.E. et al. J. Org. Chem. JOCEAH 48, 3819-3820 1983 . treatment of osteoporosis in comb, with growth hormone secretogogue WO 9 853 827 Ramoz Univ. appl. 22.5.1998 IL-prior. 30.5.1997 . - Formulation s amp. 5 jig ml 1 ml, 2 ml, 5...
COOH Akk
1 -methyl-indazole-3-carboxylic acid 1 -methyl-indazole-3-carbonyl chloride 1 -methyl-indazole-3-carbonyl chloride
H Whh
EP 200 444 Beecham appl. 21.4.1986 GB-prior. 27.4.1985, 21.10.1985 . Bermudez, J. et al. Bioorg. Med. Chem. Lett. BMCLE8 4 20 , 2376 1994 . WO 9 730 049 SmithKline Beecham appl. 11.2.1992 GB-prior. 13.2.1996 . synthesis o l-methylindazole-3-carboxylic acid EP 323 105 Beecham appl. 19.12.1988 GB-prior. 22.12.1987 . Bermudez, J. et al. J. Med. Chem. JMCMAR 33, 1924 1990 . Jones, G. Stanger, J. J. Chem. Soc. C JSOOAX 1969, 901. medical use for treatment ofCNS and cognitive disorders EP 223 385...
Info Hak
Offe, H.A. Z. Naturforsch., B Anorg. Chem., Org. Chem., Biochem., Biophys., Biol. ZENBAX 2, 182 1947 . FR-M 2 332 Rowa appl. 1963 . Formulation s amp. 5 g as sodium salt cps. 300 mg as zinc salt ointment 5 as sodium salt susp. 300 mg as zinc salt F Plastenan Isopharm Plastenan Neomycine I Plastenan Italfarmaco RN 59277-89-3 MF C8HnN503 MW 225.21 EINECS 261-685-1 LD50 1000 mg kg M, i.p. 1118 mg kg M, i.V. gt 10000 mg kg M, p.o. 1118 mg kg M, s.c. 860 mg kg R, i.p. 910 mg kg R, i.V. gt 20000 mg...
Info Upc
FR 812 032 Soc. Franc, de Rech. Biochimiques appl. 1936 . Trade Name s F Tonicorine Lematte et Boinot wfm RN 54-30-8 MF Cl9H32N202 MW 320.48 EINECS 200-202-0 LD5 1 760 mg kg M, p.o. 2 RN 5892-41-1 MF C19H32N202 2HC1 MW 393.40 EINECS 227-571-0 LDS0 49.2 mg kg M, i.V. 760 mg kg M, p.o. gt 15 g kg R, p.o. 2-diethylaminoethyl Chloride hydrochloride Formulation s amp. 24 mg ml drg. 60 mg suppos. 40 mg Avafortan ASTA Medica -comb. wfm Avamigran Degussa Pharma ASTA -comb. wfm Spasmo-Urolong Thiemann...
Cp
GB 1 082 445 J. P. M. Raudnitz, H. Wahl appl. 2.12.1965 F-prior. 3.12.1964 . Formulation s amp. 5 mg suppos. 25 mg tabl. 15 mg Trade Name s F Sultroponium B Bioth rax wfm Use antimigraine agent, selective 5-HTr receptor agonist RN 103628-46-2 MF C14H2,N302S MW 295.41 CN RN 103628-48-4 MF Cl4H21N302S C4H604 MW 413.50 LD50 43.112 mg kg R, i.V. gt 2.939 g kg R, p.o. 4-hydrazino phenyl-N-methyl-methanesulfonamide Ii Ii
Dihydroergotoxineatc CAE
Dihydroergocornine Dihydro-oc-ergocryptine Use sympatholytic, cognition adjuvant RN 11032-41-0 MF unspecified MW unspecified LD50 71 mg kg M, s.c. CN dihydroergotoxine RN 8067-24-1 MF unspecified MW unspecified ergocornine ergocristine ergccryptine A 1 1 1 ergocornine ergocristine ergccryptine A 1 1 1 9,10 Dihydroergocornine 9,1 O-Dihydroergocristine 9,10-Dihydroergocryptine A R Stoll, A. Hofmann, A. Helv. Chim. Acta HCACAV 26, 2070 1943 . DE 883 153 Sandoz appl. 1941 CH-prior. 1940 . DOS 2...
HCHO Xac
HI 7-chloro-5- phenyl iv HI US 3 987 052 Upjohn 19.10.1976 appl. 29.10.1969 USA-prior. 17.3.1969 . US 3 980 789 Upjohn 14.9.1976 appl. 19.6.1972 USA-prior. 29.3.1971 . DE 1 955 349 Takeda D-prior. 4.11.1969 . GB 1 298 364 Upjohn GB-prior. 27.10.1969 . a DOS 2 203 782 Upjohn appl. 27.1.1972 USA-prior. 9.2.1971 . US 3 709 898 Upjohn 9.1.1973 prior. 9.2.1971 . US 3 781 289 Upjohn 25.12.1973 prior. 11.5.1972 . b DOS 2 012 190 Upjohn appl. 14.3.1970 USA-prior. 17.3.1969 . Formulation s tabl. 0.25...
Info Jjy
2. acidic ion exchanger, NoHCOj US 2 671 752 Syntex 1954 appl. 1951 . Djerassi, C. et al. J. Am. Chem. Soc. JACSAT 82, 2318 1960 . Marker, R.E. Crooks, H.M. J. Am. Chem. Soc. JACSAT 64, 1280 1942 . alternative syntheses US 3 557 158 Upjohn 19.1.1971 appl. 22.1.1962 prior. 4.8.1958 . Schneider, P. et al. J. Am. Chem. Soc. JACSAT 81, 3167 1959 . GB 850 263 Organon appl. 30.4.1959 NL-prior. 12.5.1958 . US 4 041 055 Upjohn 9.8.1977 appl. 17.11.1975 . DE 1 134 075 Merck AG appl. 26.11.1959 ....
V Mnh
O CHj 2. 2-diethylamino- I ethyl chloride DE 1 964 712 C.E.R.P.H.A. appl. 23.12.1969 F-prior. 26.12.1968 . US 3 818 021 C.E.R.P.H.A. 18.6.1974 F-prior. 24.12.1968 . Trade Name s F Suplexedil Anphar-Rolland wfm RN 15302-16-6 MF CuH12N202 MW 204.23 EINECS 239-339-6 CN
Info Uvp
GB 1 114 660 Tanabe Seiyaku appl. 5.12.1966 I-prior. 8.12.1965, 9.6.1966, 22.7.1966 . ZA 6 802 416 Tanabe Seiyaku 11.9.1968 J-prior. 27.4.1967 . Formulation s powder 1 , tabl. 3 mg vial 0.1 mg as hydrochloride I Vems ISF wfm Vems Searle wfm J Inolin Tanabe Triamcinolone ATC AOlACOl D07AB09 D07BB03 D07CB01 D07XB02 H02AB08 S01BA05 S02CA04 Use glucocorticoid RN 124-94-7 MF C21H27F06 MW 394.44 EINECS 204-718-7 LD5 gt 4 g kg M, s.c. 99 mg kg R, s.c. CN 11 , 16oc -9-fluoro-11,16,17,21 1. Arthrobocter...
Info Ior
WO 9 506 052 Merck amp Co. USA-prior. 25.8.1993 . WO 9 533 756 Merck amp Co. appl. 2.6.1995 USA-prior. 6.6.1994 . US 5 510 517 Merck amp Co. 2.3.1995 USA-prior. 25.8.1993 . DE 3 016 289 Henkel KG D-prior. 28.4.1980 . BE896 453 1st. Gentili s. p. a. appl. 14.4.1983 I-prior. 15.4.1982,16.2.1983 . BE903 513 1st. Gentili s. p. a. appl. 25.10.1985 I-prior. 29.10.1984 . EP494 844 1st. Gentili s. p. a. appl. 2.1.1992 I-prior. 8.1.1991 . US 4 621 077 1st. Gentili s. p. a. 8.6.1984 I-prior. 15.4.1982 ....
H Ull
II BE 611 000 Sterling Drug appl. 30.11.1961 USA-prior. 1.12.1960 . Archer, S. et al. J. Med. Chem. JMCMAR 7, 123 1964 . Formulation s amp. 30 mg ml cps. 50 mg, 56.4 mg suppos. 50 mg tabl. 25 mg Trade Name s D Fortrai Winthrop GB Fortagesic Sanofi Fortrai Sterwin as F Fortal Sanofi Winthrop Winthrop as hydrochloride I Pentalgina Pierrel Talwintab Sanofi Pentagin Sankyo Talwin Pierrel Winthrop USA Talacen Sanofi Talwin Sanofi Winthrop J Peltazon Grelan Talwin Sanofi Pentylenetetrazol Use...
Info Mys
DOS 2 313 361 Heumann appl. 17.3.1973 . also further methods Liebenow, W. Prikryl, J. J. Antimicrob. Chemother. JACHDX 5, Suppl. B , 15 1979 . Formulation s sol. 25 mg 5 ml, 100 mg 5 ml tabl. 100 mg in comb, with sulfadiazine Trade Name s D Sterinor Heumann -comb. I Oxosint Medivis -comb. Sterinor ABC -comb. ATC R01AA06 R01AB03 S01GA02 Use vasoconstrictor RN 84-22-0 MF CBH16N2 MW 200.29 EINECS 201-522-3 LDS0 48.1 mg kg M, i.V. 335 mg kg M, p.o. CN RN 522-48-5 MF C13H16N2 HCl MW 236.75 EINECS...
Info Ndc
Thuillier, G. Rumpf, P. Thuillier, J. C. R. Hebd. Seances Acad. Sci. COREAF 249, 2081 1959 . FR 398 M Centre Nat'l. Recherche Sci., appl. 15.4.1959 . Formulation s amp. 250 mg, 500 mg, 2 g as hydrochloride drg. 200 mg, 500 mg f. c. tabl. 100 mg, 250 mg D CERUTIL Isis Pharma F Helfergin Promonta Lundbeck Isis Pharma as GB hydrochloride Lucidril Lipha Sant as hydrochloride Lucidril Reckitt amp Colman wfm Lucidril Bracco wfm Lucidril Dainippon Meclon Toho Mecroeat Hishiyama Proseryl Funai
HC Iib
F Cantor Clin-Comar-Byla Cantor Clin-Midy wfm J Alcas Taisho 1980 wfm I Cantor Midy 1984 RN 10118-90-8 MF C23H27N307 MW 457.48 LD50 140 mg kg M, i.V. 3100 mg kg M, p.o. CN 4S- 4a,4aa,5aa,l -dioxo-2-naphthacenecarboxamide RN 13614-98-7 MF C23H27N307 HCl MW 493.94 EINECS 237-099-7 LDS0 154 mg kg M, i.V. 3600 mg kg M, p.o. 164 mg kg R, i.V. 2380 mg kg R, p.o. US 3 148 212 American Cyanamid 8.9.1964 appl. 22.12.1961 . US 3 226 436 American Cyanamid 28.12.1965 prior. 24.10.1961, 22.12.1961,...
H Byg
a EP 196 132 Janssen Pharmaceutica N. V. appl. 13.3.1986 USA-prior. 27.3.1985 5.2.1986 . b ES 2 074 966 Vita-invest, S. A. appl. 16.9.1995 E-prior. 11.2.1994 . preparation of Strupczewski, J.T. Allen, R.C. Gardner, B.A. Schmid, B.L. St che, U. J. Med. Chem. JMCMAR 28 6 , 761 1985 . preparation o tetrahydropyran-4-carboxylic acid Radiszewski, J.G. Kaszynski, P. Littmann, D. Balaji, V Hess, B.A. Michl, J. J. Am. Chem. Soc. JACSAT 115 18 , 8401 1993 Straessler, C. Linden, A. Heimgartner, H. Helv....
Info Wrb
US 3 312 591 Glaxo 4.4.1967 GB-prior. 10.5.1963, 28.1.1964 . US 3 312 590 Glaxo 4.4.1967 GB-prior. 11.6.1963, 28.1.1964 . DE 1 443 957 Glaxo appl. 10.6.1964 GB-prior. 11.6.1963, 28.1.1964 . Ferrante, M.C. Rudy, B.C. Anal. Profiles Drug Subst. APDSB7 6,43 1977 . Formulation s aerosol 0.1 amp. 5 mg ml cream 0.05 ointment 0.05 Trade Name s D Diprogenta Essex Pharma -comb. Diprosalic Essex Pharma -comb. Diprosis Essex Pharma Diprosone Essex Pharma Diprosone depot Essex GB Pharma -comb. F Diprolene...
H Adx
Schaeffer, H J. et al. Nature London NATUAS 272, 583 1978 . DE 2 539 963 Wellcome appl. 2.9.1975 GB-prior. 2.9.1974 . US 4 199 574 Wellcome 22.4.1980 GB-prior. 2.9.1974 . GB 1 523 865 Burroughs Wellcome GB-prior. 2.9.1974 . c GB 1 567 671 Wellcome appl. 26.8.1977 USA-prior. 27.8.1976 . Matsumoto, H. et al. Chem. Pharm. Bull. CPBTAL 36, 1153 1988 . f EP 709 385 Roche appl. 13.7.1995 USA-prior. 26.7.1994, 27.4.1995 . alternative synthesis from 4-aminoimidazole-5-carboxamide WO9 Oil 283 GEA Farm....
OH Djc
DRP 152 814 Hoechst 1903 . Formulation s 60 mg stick RN 56287-74-2 MF C16HI4FN30 MW 283.31 LDS0 397 mg kg M, p.o. 249 mg kg R, p.o. CN RN 56287-75-3 MF C16H14FN30 xHCl MW unspecified
Efonidipine hydrochloride ethanol
Use antihypertensive, calcium channel blocker RN 111011-76-8 MF C34H38N307P C2H60 HC1 MW 714.20 LDS0 gt 5 g kg R, p.o. CN pyridinecarboxylic acid 2- phenyl phenylmethyl amino ethyl ester f-oxide monohydrochloride compd. with ethanol 1 1 RN 111011-63-3 MF C34H38N307P MW 631.67 hydrochloride RN 111011-53-1 MF C34H38N307P HC1 MW 668.13 R -base RN 128194-13-8 MF C34H38N307P MW 631.67 S -base RN 128194-12-7 MF C34H38N307P MW 631.67 2,2-dimethyltrimethylene acetonylphosphonote I...
Info Ukk
DOS 2 150 268 Schering AG appl. 4.10.1971 . DOS 2 204 361 Schering AG appl. 27.1.1972 . DOS 2 260 303 Schering AG appl. 6.12.1972 . GB 1 387 911 Schering AG valid from 19.3.1975 D-prior. 4.10.1971,27.1.1972 . Laurent, H. et al. Arzneim.-Forsch. ARZNAD 27 II , 2187 1977 also other methods . DOS 2 441 284 Schering AG appl. 27.8.1974 . BE 823 682 Schering AG appl. 20.12.1974 D-prior. 21.12.1973, 27.8.1974, 16.9.1974 . Formulation s cream 7.5 mg g ointment 7.5 mg g powder 100 mg 4 g H02AB03 S01CA04...
Info Rww
Diprosalic Schering-Plough -comb. Duofilm Stiefel -comb. Gelcosal Quinoderm -comb. Ionil T Galderma -comb. Meted Euroderma Monphytol L.A.B. -comb. Movelat Sankyo -comb. Occlusal Euroderma Phytcx. Pharmax -comb. Posalfilin Norgine -comb. Pragmatar Bioglan -comb. Pyralvex Norgine -comb. Salactol Dermal -comb. Acidum salicylicum Spiroyls ure Spirs ure RN 69-72-7 MF C7H 0, MW 138.12 EINECS 200-712-3 LD50 184 mg kg M, i.V. 480 mg kg M, p.o. 891 mg kg R, p.o. CN 2-hydroxybenzoic acid RN 54-21-7 MF...
Info Hqr
4'-ethylpropio- form- piperidine DOS 2 458 638 Eisai appl. 11.12.1974 J-prior. 14.12.1973 . US 4 181 803 Eisai 1.1.1980 J-prior. 14.12.1973 . US 39 995 047 Eisai 30.11.1976 J-prior. 14.12.1973 . alternative syntheses JP 7 930 178 Asahi appl. 5.8.1977 . JP 7 932 480 Asahi appl. 19.8.1977 . JP 7 936 274 Asahi appl. 24.8.1977 . Formulation s tabl. 50 mg as hydrochloride Trade Name s J Atines Takeda Dechozyl Sawai Epenard Taiyo Epeso Teikoku Evonton Tatsumi Miolease Hotta Myonabase Kotobuki Myonal...
Info Nsz
RN 671-16-9 MF C12H19N30 MW 221.30 EINECS 211-582-2 LD,0 614 mg kg M, i.p. gt 400 mg kg R, i.p. 350 mg kg R, route unreported CN RN 366-70-1 MF C12H19N30 HCl MW 257.77 EINECS 206-678-6 LD,0 540 mg kg M, i.V. 560 mg kg M, p.o. 350 mg kg R, i.V. 570 mg kg R, p.o. 1,2-bis benzyloxycorbonyl -1 -methylhydrazine, sodium hydride 1,2-bis benzyloxycorbonyl -1 -methylhydrazine, sodium hydride US 3 520 926 Roche 21.7.1970 CH-prior. 9.6.1961 . GB 968 460 Roche appl. 7.6.1962 CH-prior. 9.6.1961 . Zeller, P....
Info Udn
II GB 1 501 150 Nisshin Hour Milling Co. GB-prior. 11.7.1975 DE 2 631 080 Nisshin Flour Milling Co. appl. 9.7.1976 GB-prior. 11.7.1975 . synthetic preparation of A'-methyl-4-hydroxyisocarbostyril Lombardino, J.G. J. Heterocycl. Chem. JHTCAD 7 5 , 1057 1970 . synthetic preparation ofphthalic acid monoamide diethyl esters JP 57 054 152 Nisshin Flour Milling Co. J-prior. 18.9.1980 . JP 0 108 595 Nisshin Hour Milling Co. J-prior. 2.9.1988 . Formulation s tabl. 10 mg, 20 mg as hydrochloride J Daim...
Info Flq
US 4 292 317 Roger Bellon 29.9.1981 appl. 15.9.1978 GB-prior. 20.9.1977 . DOS 2 840 910 Lab. Roger Bellon appl. 20.9.1978 GB-prior. 20.9.1977 . Gouffon, G. et al. C. R. Hebd. Seances Acad. Sei. COREAF 292 1981 . Formulation s f. c. tabl. 400 mg inj. soi. 400 mg 125 ml, 400 mg 5 ml as mesylate Trade Name s D Peflacin Rh ne-Poulenc F Peflazine Bellon Rh ne- I Peflacin Rh ne-Poulenc Rorer Poulenc 1985 Pharma rn 69372-19-6 MF cinh n60 MW 228.22 cn rn 100299-08-9 MF cl0h7kn6o MW 266.31 LD50 220 mg...
Info Vyk
H OyCFj Cl2, hy CI-___OyCF3 KF 1,1,1,3.3,3-hexo- 1,1, 1,3,3.3-hexo- a DEI 954 268 Baxter appl. 28.10.1969 USA-prior. 29.10.1968 . US 3 683 092 Baxter 8.8.1972 appl. 31.7.1970 prior. 28.10.1968 . EP 341 005 BOC appl. 28.4.1989 USA-prior. 6.5.1988 . US 4 874 901 BOC 17.10.1989 appl. 6.5.1988 . b US 4 874 902 BOC 17.10.1989 appl. 20.5.1988 . EP 42 412 Baxter Travenol appl. 10.12.1980 USA-prior. 26.12.1979 . Formulation s inhalation sol. 1 ml Trade Name s D Sevorane Abbott J Sevofrane Maruishi 1990...
Methylmethionine sulfonium chlorideatc a
Methiosulfonii chloridum MMS Vitamin U Use Peptic ulcer therapeutic, antidote RN 1115-84-0 MF C6H14C1N02S MW 199.70 EINECS 214-231-1 LD50 259 mg kg M, i.v. gt 6 g kg M, p.o. 432 mg kg R, i.v. gt 6 g kg R, p.o. CN chloride RN 33515-11-6 MF C6H14BrN02S MW 244.15 iodide RN 3493-11-6 MF C6H14IN02S MW 291.15 DE 1 239 697 Degussa appl. 20.2.1963 . therapy of renal diseases US 4 122 189 Kaken 24.10.1978 J-prior. 31.3.1976 . GB 1 538 000 Kaken appl. 30.3.1977 J-prior. 31.3.1976 . DOS 2 714 391 Kaken...
H Ojh
US 3 567 710 Hoffmann-La Roche 2.3.1971 prior. 3.6.1968 . alternative synthesis by reaction o 2-diethylaminoethyl chloride with GB 1 040 548 Roche appl. 1.3.1963 USA-prior. 2.3.1962 . Formulation s cps. 10 mg, 15 mg tabl. 27.42 mg as base cps. 15 mg, 30 mg tabl. 30 mg as monohydrochloride cps. 15 mg, 30 mg s. r. cps. 20 mg as dihydrochloride Flurazepam 15 30 Riker 3M Medica Staurodorm Neu Dolorgiet GB Dalmane Roche I Dalmadorm Roche Felison Bayropharm Flunox Boehringer Mannh. Midorm A.R. Piam...
N Cus
DOS 2 503 992 Rotta Research appl. 31.1.1975 I-prior. 1.2.1974 . US 4 004 008 Rotta Research 18.1.1977 I-prior. 1.2.1974 . Formulation s amp. 50 mg 3 ml s. r. cps. 200 mg suppos. 200 mg tabl. 100 mg as hydrochloride Trade Name s D Alfospas Opfermann I Alfospas Rottapharm Maiorad Rotta Research Tixocortol pivalate atq A07EA05 R01AD07 Tiocortisol pivalate Tixocortol trimethylacetate Use glucocorticoid RN 55560-96-8 MF C26H3805S MW 462.65 EINECS 259-706-4 CN 1 RN 61951-99-3 MF C21H3 04S MW 378.53...
H Ibv
diethyl 1 -methyl-butyl malonate I US 1 954 429 Eli Lilly 1934 CDN-prior. 1930 . Formulation s cps. 50 mg, 100 mg powder 50 mg as sodium sait Solamin Ardeypharm -comb. wfm Tempidorm Roland -comb. wfm Dinoctin Spret-Mauchant -comb. wfm Divinoctal I.S.H. -comb. wfm Imm noctal Houd wfm Imm noctal I.S.H. wfm Insomnyl Elert -comb. wfm GB Seconal Sodium Lilly I Immenox Roussel-Maestretti wfm Neogratusminal Simes -comb. wfm Vesparax UCB -comb. wfm J lonal Sodium Yoshitomi USA Seconal Sodium Lilly...
Info Ffa
US 2 970 082 Walker Labs. 31.1.1961 appl. 7.10.1958 . Formulation s tabl. 125 mg Trade Name s USA Nicalex Merrell-National wfm RN 150-59-4 MF C20H27N MW 281.44 EINECS 205-763-5 CN RN 5560-59-8 MF C20H27N C6H807 MW 473.57 EINECS 226-929-3 a K lz, F. et al. Ber. Dtsch. Chem. Ges. BDCGAS 72, 2161 1939 . b St hmer, W. Elbr chter, E.-A. Arch. Pharm. Ber. Dtsch. Pharm. Ges. APBDAJ 287, 139 1954 . Formulation s inj. sol. 40 mg 2 ml suppos. 80 mg tabl. 40 mg Trade Name s D Spasmocol Norgine - comb. wfm...
HC Sgb
DE 1 075 114 E. Merck AG appl. 29.4.1958 . Br ckner, K. et al. Chem. Ber. CHBEAM 94, 1225 1961 . Formulation s tabl. 2 mg, 5 mg Trade Name s D Chlormadinon Jenapharm Gestafortin Merck Gestamestrol Hermal-Chemie -comb. Menova Merck -comb. Neo-Eunomin Griinenthal -comb. F Luteran Solymes RN 62-37-3 MF C5HnClHgN202 MW 367.20 EINECS 200-530-4 LD50 215 mg kg M, p.o. 150 mg kg R, p.o. CN US 2 635 982 Lakeside Labs. 1953 prior. 1951 . Formulation s amp. tabl. 18 mg Trade Name s RN 80-77-3 MF...
H Est
DE 1 695 201 Hoffmann-La Roche appl. 21.9.1967 CH-prior. 28.10.1966, 24.4.1967, 17.7.1967 . US 3 654 357 Roche 4.4.1972 CH-prior. 26.4.1968 . US 3 787 491 Hoffmann-La Roche 22.1.1974 prior. 29.9.1971 . US 3 860 724 Hoffmann-La Roche 14.1.1975 prior. 29.9.1971 . D Gluborid Griinenthal F Glutril Roche 1972 Glutril ICN 1972 GB Glutril Roche 1975 wfm RN 21187-98-4 MF C15H21Ns03S MW 323.42 EINECS 244-260-5 LD,0 295 mg kg M, i.v. 3 g kg M, p.o. 382 mg kg R, i.V. 3 g kg R, p.o. CN...
Info Vkf
a US 2 280 040 SMA Corp. 1942 appl. 1939 . US 2 314 843 American Cyanamid 1943 appl. 1941 . US 2 993 051 Cowles Chem. Comp. 18.7.1961 appl. 26.2.1958 . b US 2 904 552 Distillers 15.9.1959 appl. 21.7.1958 . DAS 2 539 435 Showa Denko appl. 4.9.1975 J-prior. 11.9.1974 . Formulation s amp. 100 mg tabl. 200 mg numerous combination preparations F Nicobion 500 Astra further combination preparations GB Papulex Euroderma generic and combination preparations I Eparolo Bonomelli -comb. Farmobion Pp...
H Njd
DE 1 293 774 Sience-Union et Cie., Soc. Fran . de Recherche M dicale appl. 22.6.1965 USA-prior. 27.7.1964 . GB 1 078 186 Sience-Union et Cie., Soc. Fran . de Recherche M dicale appl. 16.6.1965 USA-prior. 27.7.1964 . EP 2 531 146 R. J. Wurtman et al. USA-prior. 16.6.1987 . medical use for intermittent carbohydrate craving EP 53 175 J. R.Wurtman et al. appl. 15.6.1981 USA-prior. 16.6.1980 . hydrochloride wfm F Isomeride Ardix as hydrochloride wfm hydrochloride wfm I Glypolix Servier as...
Colistin Pentasodium Mesilate
Lyophilizationof n-hexadecan-l-ol, tyloxapol solution in 0.1 n NaCl. US 4 826 821 The Regents of the Univ. of California 2.5.1989 appl. 5.11.1986 prior. 26.6.1985, 17.10.1983 . EP 50 793 The Regents of the Univ. of California appl. 14.10.1981 USA-prior. 24.10.1980 . D Exosurf Glaxo Wellcome I GB Exosurf Neonatal Glaxo Wellcome 1991 Exosurf Neonatate Glaxo USA Exosurf Glaxo Wellcome Wellcome 1991 Colistin A B Polymyxin E Use antibiotic macrocyclic peptide RN 1066-17-7 MF unspecified MW...
Info Mdk
Oxal Saita wfm Reugaril Farber-Ref wfm Reulin Isola-Ibi wfm Reumital Farge wfm b DE 1 028 999 Thomae appl. 1956 addition to DE 1 021 848 . Formulations tabl. 200 mg I Atossipirina Borromeo -comb. wfm Betix Saba wfm Megapir Biotrading -comb. wfm Ossazin Sealari wfm Ossazone Brocchieri wfm RN 95-25-0 MF C7H4C1N02 MW 169.57 EINECS 202-403-9 LD50 440 mg kg M, p.o. 763 mg kg R, p.o. CN 5-chloro-2 3f -benzoxazoIone
Info Twn
US 2 847 474 USV 1958 appl. 1954 . cf. also anismdione Formulation s amp. 8 mg 4 ml Trade Name s RN 496-67-3 MF C H , rN,02 MW 223.07 EINECS 207-825-7 ' LDW 2 g kg M, p.o. 1 g kg R, p.o. CN DRP 185 962 Knoll 1906 . Formulation s drg. 20 mg, 50 mg Trade Name s D Brom-Nervacit Herbert -comb. wfm Diffucord, -N Dolorgiet -comb. wfm Rebuso Tabletten Ravensberg -comb. wfm Steno-Valocordin Promonta -comb. wfm Tempidorm N Roland -comb. wfm Valocordin Promonta -comb. wfm Ventrivcrt Tabletten Dolorgiet...
Gusperimus trihydrochlorideatc LiL
BMY-42215-1 BMS-181173 Deoxyspergualin Use antineoplastic, immunosuppressive, hydrochloride DSG NKT-01 NSC-356894 multiple scleros's thcraPeuti,c . RN 85468-01-5 MF C17H37N703 3HC1 MW 496.91 LD50 35 mg kg M, i.v. CN RN 84937-45-1 MF C17H37N703 3HC1 MW 496.91 LD50 35 mg kg M, i.v. base racemate RN 104317-84-2 MF C,7H37N703 MW 387.53 S- - -base RN 89149-10-0 MF C17H37N703 MW 387.53 fi- -base RN 114760-38-2 MF C17H37N703 MW 387.53 S- - -hydrochloride RN 128488-79-9 MF C17H37N703 xHCl MW...
Gallium nitrate
Use hypocalcemic agent against cancer-related hypercalcemia RN 13494-90-1 MF GaN309 MW 255.74 EINECS 236-815-5 LDS0 55 mg kg M, i.V. 4360 mg kg M, p.o. 600 mg kg M, s.c. 46 mg kg R, i.v. CN gallium nitrate Dupre, A. C. R. Hebd. Seances Acad. Sci. COREAF 86, 721 1878 medical use as hypocalcemic agent EP 109 564 Sloan Kettering Inst. appl. 21.10.1983 USA-prior. 22.10.1982 . US 4 529 593 Sloan Kettering Inst. 16.7.1985 prior. 20.6.1984, 22.10.1982 . medical use as antitumor effect enhancer JP 1...
HCI Hyc
ethyl Alternatively to the Japp-Klingemann reaction phenylpyruvic acid or ethyl phenylpyruvatc can be condensed with 4-chlorophenylhydrazine. a,bUS 3 109 843 Hoffmann-La Roche 5.11.1963 appl. 21.6.1962 prior. 28.7.1961 . US 3 136 815 Hoffmann-La Roche 9.6.1964 USA-prior. 10.12.1959 . DE 1 136 709 Hoffmann-La Roche appl. 7.12.1960 USA-prior. 10.12.1959 . DEI 145 626 Hoffmann-La Roche appl. 7.12.1960 USA Prior. 10.12.1959 . DE 1 290 143 Hoffmann-La Roche prior. 7.12.1960 . US 3 371 085 Roche...